A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein ... - Nature

Summary

The article outlines a synthetic route for making C5a-aminomethyl IFG scaffolds, valuable in developing chemical chaperones for glucosidase enzymes like β-glucosidase (GCase), with implications for treating Gaucher disease. Key terms like 'hydrogenation' reflect synthetic steps, and tags such as 'β-Glucosidase' denote the targeted enzyme.