Polarized HLA Class I Expression on Renal Tubules Hinders the Detectio | IJN - Dove Medical Press

Summary

The article examines the use of extracellular vesicles (EVs) in kidney transplantation to monitor organ function and rejection. It explores the polarized membrane expression of HLA class I molecules in the kidney, their role in immune system interactions, and the detection of HLA class I+ EVs in urine and plasma, utilizing techniques such as IFCM and TR-FIA. The findings suggest that HLA class I+ EVs are not significantly excreted in urine due to their basolateral membrane localization, limiting their appearance in urine EVs and suggesting plasma as a more viable source for detection. This has implications for noninvasive monitoring methods in transplantation medicine.