Potent human neutralizing antibodies against Nipah virus derived from two ancestral ...

Summary

The article thematically focuses on immunology and biotechnology, emphasizing the identification, affinity maturation, and characterization of monoclonal and polyclonal antibodies targeting glycoproteins on henipaviruses. It includes epitope mapping of the antibodies, revealing their mechanism for neutralizing antigen binding and preventing immune evasion. The tags reflect the processes (such as immunoglobulin affinity maturation), antibody types (like monoclonal, polyclonal, and neutralizing antibodies), and proteins (coronavirus spike protein, m102.4 antibody) instrumental in immune recognition and response in the context of viral infections such as Henipavirus and, broadly, coronaviruses.