Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies)

Retrieved on: 2021-10-07 19:41:15

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Branches of biology

Proteins

Cell biology

Electron microscopy

Protein structure

Single-domain antibody

Cryogenic electron microscopy

Fragment antigen-binding

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Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). View article details on hiswai:

Excerpt

Our first nanobody-interacting scaffold is a Fab fragment of an antibody that ... To generate such a Fab, we raised monoclonal antibodies in mice against a ...

Article found on: www.pnas.org

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