Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau

Summary

The article text discusses the use of monoclonal antibodies, particularly focusing on tau-targeting antibodies for Alzheimer's disease. It explores the potential of synthetic in vitro-transcribed messenger RNA (mRNA) to encode these antibodies for endogenous expression, also addressing the production challenges and the delivery of intrabodies via mRNA to target intracellular tau. The key concept of biotechnology is exemplified by the generation and application of mRNA-encoded antibodies, utilizing techniques from immunology, molecular biology, and RNA therapeutics. The tags relate to the components involved in the process, such as monoclonal and single-domain antibodies, the tau protein, gene expression, RNA, the hepatocyte growth factor receptor, and the potential therapeutic approach towards Alzheimer's disease.