Prognostic DNA mutation and mRNA expression analysis of perineural invasion in oral ...

Summary

The article details a bioinformatics study on oral squamous cell carcinoma (OSCC), focusing on prognostic DNA mutations associated with perineural invasion (PNI) using the Cancer Genome Atlas and Gene Expression Omnibus datasets. The study identifies gene sets and pathways correlated with OSCC prognosis and explores the relationship between gene mutations and mRNA expression in PNI. Key findings involve ATM serine/threonine kinase, genomics, molecular biology techniques like microarrays, and methods such as gene set enrichment analysis.